Methyl Factors 60 Capsules


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Methyl Factors has been developed to provide extra methyl donor nutrients. It combines TMG, vitamin B6, folic acid, vitamin B12, vitamin B2 and vitamin B1 - all of these nutrients can donate methyl groups.

  • TMG, vitamin B6, vitamin B12 and methylfolate collectively provide methyl donor nutrients
  • TMG is not the same as betaine HCL, which is not necessarily a methyl donor but is sometimes used erroneously for this purpose. 
  • Folic acid is included as methylfolate (5-MTHF) which is a stable and methylated form of folate. Methylfolate fulfils all the known uses of folic acid. Many supplements contain folic acid, however, folic acid has to undergo a number of steps within the body in order to be converted to the active form – 5-MTHF. The final step in this conversion is carried out in the body by an enzyme called MTHFR and some people have genetic mutations which means this enzyme has reduced efficiency in converting folic acid to 5-MTHF. Methylfolate does not need to be converted; it is in the active form, ready for use by the body
  • This formula includes vitamin B6 in the form of pyridoxal-5-phosphate, the bio-active and enzymatically converted form of B6. There is evidence to show that some people with high homocysteine, for instance, and impaired methylation, lack the ability to effectively convert pyridoxine (the other supplement form of B6) to its metabolically active form
  • This supplement includes vitamin B12 as methylcobalamin, an active form of B12. Some vitamin B12 products on the market are cyanocobalamin which needs to be enzymatically converted to methylcobalamin in the body. Vegan and vegetarian diets can be low in B12. Other people at risk of low B12 include those with digestive conditions that lead to malabsorption; low stomach acid (e.g. due to long-term antacid medication, proton pump inhibitors, H2 blockers, ageing or zinc deficiency); surgery where nitrous oxide has been used as an anaesthetic; and other prescription medications which impair B12 absorption (e.g. metformin, colchicine, neomycin and others)
  • Folate, vitamin B12, betaine and vitamin B6 all contribute to normal homocysteine metabolism. High homocysteine is a risk factor for cardiovascular disease and cognitive decline
  • Please note that this product is only recommended for use under the guidance of a practitioner
Methyl Factors - 1 capsule will provide on average:
Active Nutrient Strength %NRV*
Vitamin B1 (as benfotiamine) 25mg 2272
Trimethylglycine 400mg *
Vitamin B2 (riboflavin 5-phosphate) 3mg 214
Vitamin B6 (as pyridoxal-5-phosphate) 20mg 1428
Folic Acid (as methylfolate) 800µg 400
Vitamin B12 (as methylcobalamin) 1000µg 40,000
Zinc 5mg 50
+NRV = Nutritional Reference Value
* Indicates no NRV

Trimethylglycine (TMG, also known as betaine), vitamin B1(as benfotiamine), vitamin B6 (as pyridoxal-5-phosphate), zinc citrate (as citrate), Vitamin B2 (riboflavin 5-phosphate), vitamin B12 (as methylcobalamin), folic acid as (5-methyltetrahydrofolate), silicon dioxide, maltodextrin, stearic acid, hydroxypropyl methylcellulose (capsule shell).

Suggested Intake:

One capsule daily with food as a food supplement as directed by a practitioner. This product is only recommended for use under the guidance of a practitioner.

Suitable for:

Vegetarians, vegans and people with Candida and yeast sensitivities.


Pregnant or breastfeeding women should consult their doctor before taking this product. Long term daily use of 10mg or more of vitamin B6 may lead to mild tingling and numbness.

Non-Active Ingredients:

Silicon dioxide, maltodextrin, stearic acid, hydroxypropyl methylcellulose.

Non GM & Free From:

GMO, wheat, soy, dairy, added sugar, flavourings & colourings.


Keep cool, dry & out of direct sunlight. One of the ingredients in this product attracts moisture, which over time will degrade it. When this happens it turns orange and goes hard. To avoid this, the product should be kept in the pot provided and the lid closed. These capsules should not be stored in daily pill boxes for longer than 48 hours.

Category: Vegan, Women's Health